The Opportunity: The Principal Project Governance Leader is a critical global leadership role across Avantor, responsible for establishing, governing, and continuously improving the organization’s Project Management Office capability across all regions, business units, and functions. This role provides enterprise-wide governance across Avantor’s $150M annual capital expenditure (Capex) portfolio, ensuring that the organization is consistently investing in and delivering the most strategically important projects aligned to enterprise priorities. The role provides leadership across project governance, portfolio management, delivery oversight, project controls, and PMO systems to ensure projects and programs are executed in alignment with Avantor’s global strategic objectives and capital allocation priorities. Operating across a complex, multi-regional environment, the role ensures a structured, transparent, and standardized approach to Capex investment planning, delivery execution, and performance tracking. It enables senior leadership and global governance bodies to make informed decisions through consolidated portfolio insight, financial transparency, and clear visibility of risks, dependencies, and outcomes. Critically, this role is accountable not only for governance and delivery oversight, but also for ensuring that projects achieve their intended business outcomes. This includes verifying that, upon closure at Gate 5c, projects have delivered against their original business case KPIs, benefits, and strategic goals. A central focus of the role is driving global consistency, investment discipline, and value realization, ensuring that PMO standards, methodologies, and governance frameworks are applied uniformly and effectively across all regions. Remote role with 20% travel Global PMO Leadership & Strategy Lead the PMO Governance function globally across Avantor, ensuring alignment with enterprise strategy and Capex investment priorities Define and maintain a global PMO operating model supporting oversight of a $150M annual Capex portfolio Provide leadership, coaching, and capability development across global and regional teams Global Governance & Portfolio Management Establish and govern a global portfolio management framework overseeing $150M in annual Capex investment Ensure the organization is consistently prioritizing and executing the most important projects in the company Lead global demand management, prioritization, and Capex investment planning processes Support executive governance forums and investment committees in making data-driven decisions Oversee global resource and capacity planning across the Capex portfolio Maintain a single, consolidated view of portfolio performance, value delivery, and dependencies Project & Program Delivery Oversight (Global Execution ) Define and enforce global project lifecycle frameworks, including Gate 5c closure requirements Ensure consistent application of delivery methodologies across all regions Monitor project performance against approved baselines and original business case commitments Ensure projects are delivered not only on time and on budget, but also deliver the intended KPIs, benefits, and strategic outcomes Validate that projects meet their original business case objectives at Gate 5c closure Facilitate cross-regional coordination and manage global dependencies Project Controls & Performance Managemen t Implement an integrated project controls framework covering the $150M Capex portfolio Standardize performance measurement across cost, schedule, scope, risk, and benefits Oversee Capex financial tracking, forecasting, and variance analysis Establish benefits realization governance to confirm outcomes are achieved and sustained Deliver executive reporting that clearly links investment, delivery performance, and value realized PMO Systems & Tools Define global requirements for PMO and PPM tools to support portfolio prioritization and governance Enable visibility into the most strategically important projects across Avantor Support automated reporting of project performance, business case KPIs, and benefits realization Ensure data integrity and consistency across global systems Integrate project, financial, and operational systems to support end-to-end governance Information & Knowledge Management Establish global standards for project documentation, including business case and Gate 5c closure artefacts Maintain centralized repositories for PMO standards and performance insights Promote continuous improvement based on lessons learned and post-implementation reviews Capability Development & Training Develop training frameworks focused on outcome-based project delivery Drive adoption of global PMO standards and governance practices Degree in Business, Engineering, Project Management, or related field ~10+ years of progressive leadership experience in PMO field with experience in chemical, life sciences, pharmaceutical, or similarly regulated business environments. ~ Demonstrated experience leading global PMO organizations ~ Professional certifications (PMP, PgMP, PRINCE2, MSP, Agile) preferred ~ Extensive experience leading PMO functions in global, multi-regional organizations ~ Strong expertise in benefits realization management and business case validation ~ Experience ensuring projects meet defined outcomes at closure (e.g., Deep knowledge of project controls, governance, and portfolio management ~ It enables medical devices that help a little boy hear his mom's voice for the first time. We are committed to helping you on this journey through our diverse, equitable and inclusive culture which includes learning experiences to support your career growth and success. The expected pre-tax pay for this position is $We are an Equal Employment/Affirmative Action employer and VEVRAA Federal Contractor. We do not discriminate in hiring on the basis of sex, gender identity, sexual orientation, race, color, religious creed, national origin, physical or mental disability, protected Veteran status, or any other characteristic protected by federal, state/province, or local law. Privacy Policy: We will use the personal information that you have submitted to us in order to consider your application for the relevant role. Please click here for our Privacy Policy which explains the purposes for which we will use your personal information and the ways in which we will handle and retain your information. 3rd Party Non-Solicitation Policy: